The actress, who will also play the lead role in the film, is co-producing it with production house Phantom.
"I'm thrilled to get a chance to do this so early on in my career. And I couldn't have found a better project than 'NH10' to kick-start this new phase in my film journey," Anushka said in a statement.
The film will be directed by Navdeep Singh post his critically acclaimed debut `Manorama Six Feet Under`.
`NH10` is an action thriller about a road trip gone wrong.
Anushka, who recently worked with Phantom for her forthcoming project "Bombay Velvet", is looking forward to work with the production house again.
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"This is my second film after 'Bombay Velvet' with Phantom, and it's a blast working with them. It's going to be super-exciting working together again on what promises to be an explosive film," said Anushka, who will also be seen with Aamir Khan in Rajkumar Hirani's "Peekay`.
The 25-year-old follows in the footsteps of actor Ranbir Kapoor who will be co-producing "Bombay Velvet".
Being shot this winter across the northern plains around Delhi, `NH 10` will release Sep 12 next year.