The filmmaker, who died on March 1, 1994, gave many hit films such as 'Amar Akbar Anthony', 'Naseeb' and 'Parvarish' with Amitabh in the 1970s and the 1980s.
"Manmohan Desai... left us today (Tuesday) years ago, years I do not wish to remember. I miss you Man ji," Amitabh tweeted on Wednesday along with a few images featuring them on a film set.
Big B also suffered a near-fatal accident while shooting an action scene for Desai's 'Coolie' in 1982.
He took to his official blog to talk about how "memories keep going".
"Remembrance is an exercise by itself, painful and frustrating. For when you need that word or name, it just does not come. It hangs incognito at the tip of your cranial cells but refuses to give the joy of its exactitude immediately. You or rather one searches equivalent expressions to come to the right word, and so blessed for this Google thingy.
"It's the boon of the generation. But they say it's fast going out of fashion," he wrote.
He shared about shooting in Kamalistan Studio as well.
"And so to work at Kamalistan Studios... an expanse of studio land belonging to that great legend, Kamal Amrohi. The husband to Meena Kumari, the maker of so many iconic films, in particular 'Pakeeza'," the 73-year-old wrote.
"The blue and the white cross marks are the modern generation cinema technology. When it is all set and done an entire chemical laboratory shall be placed around me through which I walk... and not just me, but two more of me. I mean the same me but three of me," he expressed sharing photographs of himself in "formals, rural, aggressive and finally laid-back" looks.
He also posted a photograph of himself in which he is seen holding an award for his performance in 'Piku'.
"And my Zee Awards Best actor trophy which I could not go to receive because of my condition. Receiving it now on camera," wrote Amitabh, who is recovering from a mild ailment which laid him low.
He used the digital platform to update fans about his look in Shoojit Sircar's next.
"The beard and the hair grows for the next for Shoojit Sircar. Random and without care. Contemplative, lost in mood, bipolar in form," he wrote.