This will be the 30-year-old "Neerja" actress' first appearance at the prestigious 'Cinema Against AIDS' fundraiser.
"It's an honor to be a part of the esteemed amfAR gala. I cannot stress enough the importance of AIDS research in our time. This foundation is doing such incredible work dedicated towards raising funds for life-saving research programs that help the fight against AIDS.
"I am looking forward to meeting the wonderful team that chairs amfAR and hope to contribute to this cause in every way possible," Sonam said in a statement.
Other prominent names to attend the gala event are Helen Mirren, Sharon Stone, Katy Perry, Kenneth Cole, Lewis Hamilton, Isabeli Fontana, Barbara Palvin and Irina Shayk.
Aishwarya Rai Bachchan, who has been a regular at the fundraiser, will be giving it a miss this year due to her professional commitments.
In her sixth visit to the Cannes, Sonam will attend various parties, film premieres and charity dinners.