Amjad Khan was born to actor father Jayant in 1940. He first got a role in Ab Dilli Dur Nahin (1957), a narrative of the socio-political post- Independence India of great substance. A journey that began from here reached its zenith in Sholay in (1976). Before that he did an assistantship with the legendary K. Asif in Love and God and quite a few roles in the theatre.
His first major break was Hindustan Ki Kasam (1973). The film was made on the theme of Indo-Pak war of 1971. Sholay happened in 1975 and catapulted him to the status of a star. It is said that to create the aura of a dacoit, Amjad actually read a book Abhishapth Chambal, written about marauders of that infested the dreaded ravines. The hoarse voice, the foibles, and an unconscionable character, played by Amjad Khan to the core created the immortal Gabbar. It soon made him a sought after actor.

Parvarish, Hum Kisi Se Kum Nahin, Aakhri Goli, are some of his movies of 1977. Similarly, in 1978 came such big successes as Phool Khile Hain Gulshan Gulshan, Muqadar Ka Sikander, Kame Vaade, Heeralal Pannalal, Khoon Ki Pukaar, etc. Due to the Sholay impact; he got the opportunity to act opposite Amitabh Bachchan in many movies in the heydays of the latter. In 1979, Amjad Khan played, Vikram, a notorious smuggler that drives Amitabh Bachchan (Natwarlal) to unscrupulous ways. Hum Tere Aashique Hain, Chambal Ki Kasam, Suhaag, Bombay 405 Miles, Suhaag followed. Kaatil, Kalia, Laawaris, Yarana, Teesri Aankh, the list is very long. To sum it up there was hardly a block-buster in the late seventies and early eighties that didn't have Amjad Khan as the chief negative protagonist.

Besides other recognitions, Amjad Khan was conferred the Filmfare Award on numerous occasions for the best villain. Amjad Khan was married to Sheila in 1972 and two sons, Shadaab, Seemab and a daughter Ahlaam and was born out of the wedlock. Shadaab like his father, and grandfather is dabbles in films.