Khan, who was expected to arrive here, will be unable to pay a visit to the city due to "his visit dates clashing with his shooting schedules", the Daily Times reported.
Ajay Devgan, who also stars in the film, is yet to confirm his presence at the premier. According to the spokesman of the film festival, Devgan will confirm his participation 48 hours before the movie's premier.
Organisers also rejected the notion that there was some problem in issuing visas to the actors, that was the cause behind the actors being unable to attend the show.
Khan was not coming because of the clash with his shooting schedule, a spokesman of the festival was quoted as saying, rejecting the "notion" that the visa had been denied to him.
Khan, along with many of the artists of "Omkara", were expected to be present at next Saturday's screening of the film that is based on Shakespeare's "Othello."
Media reports here did not mention why Khan's non-arrival had been attributed to denial of visa, a frequent occurrence in India and Pakistan when non-official visits are exchanged. This would have been Saif's second visit to Pakistan, the first one being a charitable event last year for which he had accompanied Malaika Arora and Sushmita Sen.
The arrival of Ajay Devgun and other star cast would be known only 48 hours before the special screening, the organizers said.
Vishal Bhardwaj, the director of Omkara, is expected to make an appearance along with the stars.
Filmmaker Mahesh Bhatt, who is the festival's ambassador and a regular, his brother Mukesh and some other Bollywood film personalities have attended the festival that has had many Indian films screened this year.