As per preliminary information, the Tata Safari, in which her husband and noted lyricist Javed Akhtar were also travelling, dashed against a truck on the highway towards Pune at around 4.15 p.m.
The injured actress was brought out of the car and admitted to an MGM Hospital in Navi Mumbai.
It is not immediately clear whether Akhtar was also injured, but another unidentified woman is reported to be seriously hurt.
Her driver got injured in accident.
Highway police patrol teams have rushed to investigate the accident site.