"Avatar" beat other nomiees "Up in the Air", "The Hurt Locker", "Inglourious Basterds" and "Precious". Director James Cameron also won the best director award.
"A very big thank you. Thank you for believing in blue people I also want to thank the fabulous crew that made this film possible, " said producer Jon Landau.
The film that has till now grossed over $1.3 billion at the international box office, stars Sam Worthington, Zoe Saldana, Sigourney Weaver, Michelle Rodriguez and Stephen Lang.
The award was given by three time Golden Globe winner actress Julia Roberts.