These men are putting onscreen hero-heroine couples in the shade.
"In case of Arshad and Sanjay, they might not have been very good friends before coming together in 'Munnabhai', but the madness in their characters created magic on screen and their friendship grew, " said director Tarun Mansukhani.
The impeccable comic timing of Sanjay as Munnabhai and Arshad as Circuit in the franchise made them a much-sought-after pair. Both also worked together in "Dhamaal" and "Anthony Kaun Hai".
They are teaming up again for "Double Dhamaal" and "Munna Chale Amrika", which is the third in the "Munnabhai" franchise.
Sagar Ballary, who had cast Ranvir and Vinay in "Bheja Fry", won't mind working with Arshad-Sanjay jodi.
"I was having a discussion with Arshad about which actor to cast opposite him in my next film. I told him that I am a director who likes to improvise with characters, to which he replied, 'I can't improvise with anybody other than Sanjay Dutt. It just clicks with him', " he said.
Ranvir-Vinay have known each other since the time they anchored "OYE" for Channel V together. Directors tried different permutations and combinations with the two on big screen with "Dasvidaniya" and "Khosla Ka Ghosla".
Their next is "Winds of Change", based on Salman Rushdie's 1981 novel "Midnight Children".
"They are very good friends and know each other since their VJing days and that adds to the camaraderie they share, which creates magic on screen, " Ballary told.
Even action star Akshay Kumar has given a string of hits with brawny actor Suniel Shetty - "Mohra", "Hera Pheri", "Dhadkan", "Phir Hera Pheri" and "Thank You", to name a few. Not to forget that the Salman Khan- Govinda pair turned out to be a hit formula.
Director Rajkumar Santoshi is planning to recreate the magic of the 1994 movie "Andaaz Apna Apna" with Aamir Khan and Salman Khan reprising their roles as Amar and Prem in a sequel.
Mainstream directors have even experimented with gay relationships on screen, but in a humorous way.
Writer Niranjan Iyengar and filmmaker Karan Johar blended humour and drama deftly in "Kal Ho Naa Ho" to show mock intimacy between Saif Ali Khan and Shah Rukh Khan. The script had good gags and director Nikhil Advani executed it to perfection, giving male pairing a new meaning.
Karan then took things to a higher level with "Dostana", where Abhishek and John were forced to pose as a couple in love who hugged and kissed. Director Tarun Mansukhani scripted the story.
"Both the actors are good friends off-screen and their personal rapport came out nicely on screen. Both of them are poles apart physically and performance-wise. While John is more mature Abhishek is a bit childlike, but both of them complement each other very well, " said Mansukhani.
The two, first seen together in action thriller "Dhoom", will once again be seen in "Dostana 2".
"After we starred together in 'Dostana', Abhishek has nicknamed me as his 'jiggly poo'. He sends me messages on my birthday, saying 'Happy Birthday Jiggly Poo'!" said John.
"Cinema is undergoing a realistic change and there are male couples in real life that swear by each other's love. They (filmmakers) see that happening in real life and try to put similar things in their films, " said Taran Adarsh.
The Amitabh Bachchan-Dharmendra camaraderie in "Sholay", after all, remains unforgettable.