In the ad she appears with a rescued dog named Bambi, who was tormented by a group of schoolboys before being rescued by a passing motorist.
The ad, shot by ace photographer G. Venket Ram, reads, "Be an Angel: Adopt a Homeless Dog", encouraging people to adopt a dog from an animal shelter or the streets.
Krishnan also revealed her own story of how she rescued her dog, Cadbury, from the streets.
"I found him ... in Hyderabad (while) I was shooting for a film. We were just driving past, and we saw this small little puppy who was wounded ... and he couldn't walk, and he was lying in the rain, " said Trisha.
Cadbury received medical care and now is a part of her family. "He came back home with me ... and he is like the son I never had, " she said.