From Bollywood stars to the sporting fraternity, all commented and shared their feelings over Husain in the Micro-blogging site.
"Hussain's best painting gift to me..a Hanuman with 'jadi buti' flying .. given to me in Breach Candy Hospital, during Coolie episode, " actor Amitabh Bachchan tweeted.
"Another special painting he did for me .. translated my poem I wrote in Hospital, on canvas ... very special and most endearing, " Bachchan recollected.
"Very sad to hear of the passing of M F Hussain saab. A wonderful person and a great artist. May his soul rest in peace, " he commented.
"Very sad to hear that the great. M.F.Husain is no more, RIP, " Dev Anand posted.
"Oh my god. Just got to know. Our legendary artist M.F.Hussain passed way. R.I.P., " singer Shreya Ghoshal posted.
"RIP MF HUSSIAN - one of the greatest artists india has produced, " actor Ritesh Deshmukh mourned.
Actor Rahul Bose commented that the death of Hussain makes Indians hand down their heads partly in grief and partly in shame as the veteran painter was unable to spend the last few years of his life in his own nation.
"Hussain passes away. we hang our heads partly in grief & partly in shame for not being able to let him spend his last days in this country, " Rahul Bose tweeted.
Industrialist Vijay Mallaya and his son Sidhartha Mallya were sad too.
"Deeply saddened by the passing away of artist genius MF Hussain. The more famous he became the more his humility, " Vijay Mallaya posted while his son Sidhartha tweeted: "Very sad to hear of the passing of MF Husain. A true legend. He will be missed."
"M.F.Hussain could not spend his last days in his motherland! Cry, the beloved country, " controversial Bangladseshi author Taslima Nasrin reacted.
"Deeply saddened by passing of M F Husain. Giant of Indian art &wonderful personality, creative till his last breath at 95. A grt loss4 India, " politician Shashi Tharoor remarked.
Apart from the world of B-town, the Indian sporting fraternity shared their feelings and memories overTwitter.
"RIP Mr. M F Hussain..u will be missed by millions, " Indian tennis icon Sania Mirza commented.
"RIP MF Hussain.. Errrie. We spoke a lot about him at dinner last night and the paintings he gifted Leander and me in '99, " Tennis star Mahesh Bhupathi shared with his fans.
"RIP MF Hussain... True genius, " Indian Olympic gold wining shooter, Abhinav Bindra remarked.
The artist fraternity across the world and especially in India is heart-broken as the news trickled in and many tried to confirm the death news of Husain (also spelt as Hussain) in London flashed by an Indian daily first and then confirmed by his associates.
Apart from his art, which are a blend of cubism and Indian style, his youthfulness and Bohemian ways- he was often seen in barefoot- also made him a colourful living legend of contemporary art.
Indian Prime Minister Manmohan Singh called his death a national loss while President Pratibha Singh Patil called it a void never to be fulfilled.
Reports said he died in a London hospital at 2.30 am (London time) on Thursday. He died of old age, his friends said.
M F Husain, born September 17, 1915, at Pandharpur in India's Maharashtra, was on self-imposed exile in Qatar and UK among other places after he got death threats.
With the acceptance of Qatar nationality, he naturally lost the citizenship of India. But he later said "I am beyond physicality" when questioned on feelings of losing Indian citizenship.
Venue depicting his works had been ransacked too in India.
According to Forbes magazine, this self-taught artist has been called the "Picasso of India".