"Dream finally coming true. Will be acting with Robert De Niro in David O Russell's (of 'The Fighter' fame) 'The Silver Linings Playbook' next week, " Anupam wrote on microblogging site Twitter.
"'The Silver Linings Playbook' also stars Bradley Cooper, Jennifer Lawrence, Chris Tucker and Jackie Weaver. As I say 'kucch bhi ho sakta hai' (anything can happen), " he posted.
Anupam, 56, has reached out to the international market through several crossover projects in the last three decades like "Bend It Like Beckham", "Bride and Prejudice", "The Mistress of Spices" and "The Other End of the Line".
Soon after Anupam revealed the news, congratulatory messages started pouring in for him from tinsel town.
Actress Bhagyashree wrote: "@AnupamPkher A BIG CONGRATULATIONS. Life mein kuch bhì ho sakta hai."
Mahesh Bhatt: "I am proud of Anupam Kher! What a journey it has been for him. The Saaransh hero is now acting opposite Robert De Nero in The Silver Lining."
Abhishek Bachchan said: "@AnupamPkher well done AK. CONGRATULATIONS."
Pritish Nandy said: "@AnupamPkher Congratulations. You always deserve the best."
Sophie Choudry said: "That's wonderful news!Congratulations!Noon deserves it more! To of my fave actors in the same frame!Can't wait!Lots of love! @AnupamPkher."
Aman Verma said: "@AnupamPkher congratulations sir, way to go...U definitely deserve all this."