"Whoever she will marry, she will keep him very happy, " Madhavan told reporters here.
The 33-year-old actress dated model-turned-actor John Abraham for eight years before calling it quits last year.
Ever since, Bipasha has been linked to actors like Rana Daggubati, Shahid Kapoor and her "Singularity" co-star Josh Hartnett.
Madhavan is impressed with the lady.
"I feel Bipasha is a wonderful person. I don't think I have ever worked with such a wonderful co-star till date, " he said.
Romantic comedy "Jodi Breakers", directed by Ashwini Chaudhary, is a story of two individuals who break others' relationships but end up falling in love with each other.
While everyone is talking about this unusual pairing, Madhavan seems confident about their chemistry. "I believe Bipasha and I share a very good chemistry on screen."
The movie will release Feb 24. It also features Omi Vaidya, Milind Soman and Dipannita Sharma.