Kuly, who was the music producer of the band constituting Manj (Manjeet) and Surj (Surjeet), lost his battle with cancer Tuesday. He was diagnosed with a brain tumour in April last year and underwent radio and chemotherapy.
He was receiving treatment at a specialised clinic in Houston, US, at the time of his death.
His family has asked people to respect their privacy and has thanked fans and well-wishers for their continued support and condolences.
Kuly was an intrinsic part of RDB, known for giving super-hit tracks like "Aaja Mahi", "Shera di Kaum" and "Singh is Kinng".
Actor Akshay Kumar, who was lead actor of "Singh is Kinng", has mourned the loss of Kuly.
"Just heard about Kuly from RDB's sudden demise. Still reeling from the shock of the news. Such a talented guy, was behind some awesome chartbusters for many of my films. My heartfelt condolences to the RDB family. RIP Kuly," Akshay wrote on his Facebook page.
Actress Sameera Reddy tweeted, "Shocked to hear RDB's heart and soul Kuly has left us. My deepest condolences to Manj, Surj and family."