"Manisha is my lucky charm. She was in my film 'Market' and I had discussed the script of 'Market 2' with her. She liked the script. Once she is back after her treatment, I will again narrate the script to her," he said.
"Market", released in 2003, was about a woman sold to a brothel by her husband.
Manisha, 42, was operated upon in December last year in a hospital in New York. She is currently undergoing chemotherapy sessions there. Her manager Subroto Ghosh says she may return in July.
Prakash said: "Manisha is recovering well and I am in touch with her manager. I think she should be back in three to four months. I share a very good rapport with her. I have worked with her in 'Market' and 'Chaahat - Ek Nasha' and can't see 'Market 2' without her."
Manisha, who has also worked in critically acclaimed films like "Dil Se", "1942: A Love Story" and "Lajja", made her Bollywood debut with "Saudagar" in 1991.
She was last seen in Ram Gopal Varma's "Bhoot Returns".