The accident was reported around 6:30 a.m.
It is said that fire broke out in the control room of the set of the show hosted by popular comedian Kapil Sharma. There was no shoot going on at that time.
Four fire tenders were rushed to Film City to douse the blaze, sources said.
Singer Sonu Nigam, who was expected to enter the show as a guest celebrity, posted on Twitter saying: "Can you all imagine?! I get prepared for 'Comedy Nights with Kapil', and the set burns into ashes the same day."
"It is unfortunate that such an incident has occurred on the sets of 'Comedy Nights With Kapil'. There have been no casualties and we are currently in the process of assessing the extent of the damage," the official from Colors channel said in a statement.
"Meanwhile, we are focusing all our efforts to resume shooting for the show so that we have no disruption and we don't disappoint our loyal viewers," the official added.
"Comedy Nights With Kapil" airs on Colors.