Gowariker will direct the film, which will introduce Miss India Universe 2010 second runner-up Pooja Hegde in Bollywood.
Its first schedule for the epic adventure and love story set during the Indus Valley Civilzation, will begin in South Africa.
After "Jodhaa Akbar", "Mohenjo Daro" will be the second film bringing together Hrithik, Gowariker, his production banner Ashutosh Gowariker Productions Pvt. Ltd (AGPPL) and Disney India.
`There has always been a natural creative synergy between UTV and AGPPL in our previous movies. This time through our collaboration with Disney, we'll have an even greater focus on entertaining families and to top that off, I'm looking forward to working again with the Disney team," said producer Sunita Gowariker.