Ferry will design costumes for the lead actors Hrithik Roshan and Pooja Hegde as well as for the entire cast of the film, a love story set during the Indus Valley Civilzation.
"I am really thrilled to be working with Ashutosh Gowariker. When I first heard about this film, I really hoped that it wouldn't clash with my work back there and I am glad it didn't," Ferry said in a statement.
"This film excites me because there is very little known about that period and so it gives me a lot of creative space to create costumes for an era which is so ancient," she added.
Ferry, who has earlier designed costumes for Hollywood films such as "Terminator 3: Rise of the Machines", "Elysium" and "Surrogates", had received an Academy Award nomination for her work for "Maverick" and she won the Outstanding Costume for a Series Emmy for "Rome".
Gowariker, who is himself an Oscar nominated filmmaker, said: "I feel extremely proud to be working with Ms. April Ferry. I have been a great admirer of her work, especially with regards to her keen eye for detail, and I'm now delighted that she will design the costumes for 'Mohenjo Daro'."
Jointly produced by Disney India's Studio business and Ashutosh Gowariker Production Pvt. Ltd. (AGPPL), "Mohenjo Daro" will go on floors in October 2014. Its first schedule will take place in South Africa.
