The movie, produced by Mahesh and Mukesh Bhatt under their Vishesh Films banner, also features Sapna Pabbi, who plays a lead role.
"It's all a mystery but yes Debina has been paired with Ali in 'Khamoshiyan'. You will have to wait for the release of the film to figure out what is the mystery between Debina and Ali," Vikram Bhatt, who wrote the script for the film, said in a statement.
"Khamoshiyan" is set for a Jan 30 release.