Priyanka was named the Favourite Actress in a New TV series at the gala on Wednesday night.
Ecstatic with the victory, she said: "I'd like to thank everyone who voted for 'Quantico'. It is my first year in the US, and to come to another country and actually get this kind of acceptance is I guess what America is all about.
"So, thank you for accepting me, thank you to my mom, my manager, the cast and crew, the writer, ABC...everyone. I'm really overwhelmed."
The 33-year-old star was given the trophy by Hollywood action star Vin Diesel, who also gave a touching tribute to his late "Fast and Furious" co-star Paul Walker by singing the song "See you again" during the course of the show.
"Furious 7", Walker's last film before he passed away in November 2013 in a car accident, was named the Favourite Movie and the Favourite Action Movie at People's Choice Awards 2016.
Other Hollywood celebrities who received awards at the ceremony held here at the Microsoft Theater were Ellen DeGeneres, Sandra Bullock, Chris Hemsworth, Johnny Depp and Meghan Trainor.
Hosted by Jane Lynch, the gala honoured the best in movies, TV and music, on the basis of public voting.
Melissa McCarthy, Taylor Swift and Ellen DeGeneres were some of the other winners.
While McCarthy won the Favourite Comedic Movie Actress and Favourite Comedic TV Actress awards, DeGeneres took home the trophies for Favourite Daytime TV Host and Favourite Humanitarian.
The Favourite Female Artist and Favourite Pop artist awards were given to Swift.
In the movies section, Channing Tatum was chosen as the Favourite Movie Actor, while Bullock was announced as the Favourite Movie Actress. The Favourite Action Movie Actor award was taken by Chris Hemsworth and Shailene Woodley was honoured as the Favourite Action Movie Actress award.
Other winners included the Favourite Comedic Movie award to "Pitch Perfect 2", Favourite Comedic Movie Actor to Kevin Hart, Favourite Dramatic Movie to "The Martian", Favourite Dramatic Movie Actor to Johnny Depp, Favourite Dramatic Movie Actress to Dakota Johnson, Favourite Family Movie to "Minons" and Favorite Thriller Movie to "Taken 3".
On the small screen, the Favourite TV Show award was given to "The Big Bang Theory", which was even named the Favourite Network TV Comedy trophy.
The awards for Favourite Dramatic TV Actor and Actress were given to Taylor Kinney and Ellen Pompeo.
"Homeland", which featured Bollywood actress Nimrat Kaur, won the Favourite Premium Cable TV Show.
Other winners in the television category included Jim Parsons as Favourite Comedic TV Actor, "Grey's Anatomy" as Favourite Network TV Drama, "It's Always Sunny in Philadelphia" as Favourite Cable TV Comedy, "Pretty Little Liars" as Favourite Cable TV Drama, Kevin Hart and Sasha Alexander as Favourite Cable TV Actor and Actress, Dwayne Johnson and Kristen Bell as Favourite Premium Cable TV Actor and Actress among others.
Meanwhile, in music categories, singer Ed Sheeran was given the award for Favourite Male Artist, American girl group Fifth Harmony was chosen as Favourite Group and singer Shawn Mendes was given the Favourite Breakout Artist award.
The Favourite Male and Female Country Artist awards went to Blake Shelton and Carrie Underwood.
Singers Nicki Mnaj and Meghan Trainor were given the awards for Favourite Hip-Hop Artist and Favourite Album respectively. And Justin Bieber's hit single "What do you mean?" was announced as this year's Favourite Single.
Madonna was announced as the Favourite Music Icon.
Amongst other popular categories, Britney Spears was named as Favourite Social Media Celebrity; the Favourite Social Media Star award was taken by Matt Bellassai; Candy Crush Saga was picked as the Favourite Mobile Game, Super Smash Bros was named as Favourite Video Game and Connor Franta called the Favourite YouTube Star.
Apart from that, the People's Choice Awards 2016 also featured some power-packed performances by Jane Lynch, Shawn Mendes, Camila Cabello, Jason Derulo, Jordan Smith and David Foster.