The epic adventure-romance collected Rs 8.87 crore on Friday in India, a statement from the makers said.
"Mohenjo Daro" minted over $1 million in overseas box office.
On the Gulf front, the Ashutosh Gowariker directorial has incurred $472,000, while in North America, the film is estimated to close at $250,000 (currently at $207,000 with 46 screens yet to report).
The film written, produced and directed by Gowariker, is Hrithik's second collaboration with the filmmaker after the 2008 film "Jodhaa Akbar".
"Mohenjo Daro" also stars Pooja Hegde and Kabir Bedi.