Before hitting the stage, the singer held a press conference that touched on her husband's health and her new take on the lyrics of her heartfelt songs.
"The meaning of the songs have a new meaning now," Dion, 47, said. "I sung them, but now I mean it. To me, they'll be different songs. To you, maybe not."
Angelil, 73, who was previously diagnosed with throat cancer in 1999, has battled cancer three times.
The singer, who has been performing in LA since 2011, took a year-long break to take care of her husband.