The Kara-Lena relationship has been one of the highlights of Season 5 and was followed by Arrowverse's epic crossover, 'Crisis on Infinite Earths'. Lena discovering that Kara was Supergirl ended the duo's friendship and with Earth-Prime being the result of the multiverse-shattering battle, she decides to work with Lex in the new reality that was formed.
The official synopsis reads: THOMAS LENNON (`RENO 911`) GUEST STARS IN SUPERGIRL'S 100TH EPISODE - Mxyzptlk (guest star Thomas Lennon) returns with a proposition for Kara (Melissa Benoist) - what if she could go back in time and tell Lena (Katie McGrath) her secret before Lex did, would things turn out different? Looking back over key moments throughout the series, Kara must decide if she wants to change history to become friends with Lena again. Familiar faces return in this special episode. Jesse Warn directed the episode with story by Robert Rovner & Jessica Queller and teleplay by Derek Simon & Nicki Holcomb (#513).