The action-packed family drama collected Rs.15.45 crore net at the box office on Sunday, a statement said. The film had earned Rs.36.63 crore at the box office in first two days.
"Brothers" shows Akshay doing mixed martial arts along with Sidharth.
Directed by Karan Malhotra, the film is presented by Fox Star Studios.
The Dharma Productions film also stars Jacqueline Fernandez and Jackie Shroff.
Celebrities like Hrithik Roshan, Sonakshi Sinha and Arshad Warsi used words like "outstanding", "very dramatic and the best sports action" film and "an emotional family saga interlaced with the exciting world of MMA (mixed martial arts)" to describe the film.