"All my fev people are leaving one by one. Helplessly I watched them go.. RIP," Manisha posted on her Facebook page with an image in which she is seen with her uncle, who spent 16 years in exile in India.
Sushil Koirala, a survivor of tongue and lung cancers, died here on Tuesday. He was 80.
On Twitter, Manisha, who is herself a cancer survivor, wrote: "I loved him dearly. RIP."
Manisha is the granddaughter of B.P. Koirala, Nepal's first elected prime minister.