Ramamurthy will play the role of Mohinder Suresh, an Indian geneticist-turned-New York taxi driver, who following his father's disappearance discovers a secret theory - there are people in this world who have super powers.
Ramamurthy's role actually will reflect the overall theme of the new series, which, NBC says, will chronicle the lives of ordinary people who wake up with incredible abilities.
Among others, the series will feature characters like a lowly paid office worker in Japan who can teleport at will, a struggling artist in New York who can paint the future and a discontented beat cop in Los Angeles who can hear the thought of others.
The series will premiere on September 25 and will run on Mondays.
Born in Chicago to Indian parents both of whom are physicians, Ramamurthy has earlier appeared in TV shows like Casualty, Guiding Light, Ultimate Force and Grey's Anatomy.
Ramamurthy is married to actress Olga Sosnovska, star of the soap opera All My Children, and has a daughter.