In a promo of the episode, the actress-turned-author and interior designer is seen giving out answers without any inhibitions.
When Karan asks Twinkle: "What does Akshay have that the Khans don't?", she said: "Some extra inches!"
She then went on to comment: "Don't look at his (Akshay's) crotch. I meant his feet."
Twinkle expressed her views about the show on Twitter with a post that read: "Dangerous to drink Koffee with Karan Johar he always asks me this very question on every public platform! But I put him on the spot too."
Karan -- known for putting celebrities in a difficult spot by asking sensational and personal questions on the chat show -- responded: "Am not half as dangerous as you! I was more scared of you than any of my other guests!"
The show is aired on Star World and Star World HD.