Mirren, who won an Academy Award for her portrayal of Elizabeth II in the 2006 movie "The Queen", was lined up to tackle the role again in "Mother: The Indira Gandhi Story", a two-part biopic about the Indian prime minister, who was assassinated in 1984.
She has no interest in taking part in a new biopic, express.co.uk reported.
"No, no. I'm not interested in biopics or anything of the sort, " Mirren said.
"Mother: The Indira Gandhi Story" will be directed by Krishna Shah and is scheduled for release later this year.